Recognizing Phosphatidylinositol 3-Phosphate
نویسندگان
چکیده
Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.
منابع مشابه
Mechanism of substrate specificity of phosphatidylinositol phosphate kinases.
The phosphatidylinositol phosphate kinase (PIPK) family of enzymes is primarily responsible for converting singly phosphorylated phosphatidylinositol derivatives to phosphatidylinositol bisphosphates. As such, these kinases are central to many signaling and membrane trafficking processes in the eukaryotic cell. The three types of phosphatidylinositol phosphate kinases are homologous in sequence...
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عنوان ژورنال:
- Cell
دوره 107 شماره
صفحات -
تاریخ انتشار 2001